Popular in Korea and even tried by celebrity Jennifer Aniston, salmon DNA polynucleotides are favoured for their high purity and biocompatibility due to their natural origin and skin regenerative properties. These polynucleotides are used for their biostimulatory effects, enhancing collagen, elastin, cellular regeneration and improving overall skin health. Beyond that, polynucleotides are well known for their anti-inflammatory, antioxidant, and skin hydration properties. This blog explores the innovative applications of polynucleotides in aesthetic treatments, alone or in combination treatments, aiming to enhance patient outcomes and revolutionise aesthetic medicine.
What are Polynucleotides?
Originally, polynucleotides were utilised in medical therapies for their regenerative properties, particularly in wound healing and tissue repair. Polynucleotides are long chains of nucleotides made of DNA and RNA essential for cellular repair and regeneration.
In aesthetic medicine, polynucleotides are prized for their ability to stimulate fibroblast activity, boosting collagen and elastin production. This leads to improved skin texture, elasticity, and overall rejuvenation. Their biocompatibility and safety profile make them particularly suitable for aesthetic and regenerative medicine, reducing the risk of adverse reactions.
Salmon DNA polynucleotides are typically extracted from the salmon gonads that were distilled, purified and mixed into a water formula, before injection used in aesthetic medicine. It can be used on the face, neck, and hands, but its most popular use is for under the eyes.
Breakthrough Polynucleotide Applications in Aesthetics
A journal from Italy’s clinical practices published in the Journal of Cosmetic Dermatology has recently provided consensus‐based recommendations for the safe and effective use of Polynucleotides Highly Purified Technology™ (PN‐HPT™) devices for skin rejuvenation.
These treatments are particularly effective for ageing skin, providing a natural and subtle rejuvenation without the volumising effect of traditional fillers. Areas of treatment include:
| Polynucleotides | |||
| Areas of treatment | Face area, décolleté including the neck | Body areas, back of the hands | Scalp, eyebrows, beard |
Objectives | Skin rejuvenationHydrationScar improvement | Skin rejuvenationHydrationScar improvementStretch mark improvement | Normalisation of follicular activityHair growth |
Depending on individual skin needs, polynucleotide treatments can be combined with CO2 lasers, energy and light devices, HA fillers, peels, microneedling, and surgical procedures as they can reduce recovery time and improve outcomes. They accelerate healing, reduce inflammation, and enhance the overall effectiveness of these procedures. Polynucleotides can be good for post-procedure care, noting faster recovery and improved patient satisfaction.
Note: Please note that the methods outlined below are based on a specific study from Italy involving the use of PN-HPT™ gel. Different products have varying guidelines and protocols. Therefore, having adequate and specialised product training and certification in polynucleotides is essential to ensure safe and effective treatment outcomes across different polynucleotide applications.
[METHOD] Face
Intradermal injections of PN-HPT™ gel for skin rejuvenation are used in minimally invasive facial aesthetic procedures. The choice of technique depends on the physician’s expertise, determining the appropriate dose, injection volume, number of sessions, and intervals between treatments to optimise aesthetic outcomes. Facial ageing, characterised by bone resorption, decreased tissue elasticity, and fat redistribution, guides treatment selection. For advanced ageing, a 40 mg/2 mL PN-HPT™ formulation is recommended, injected intradermally every 14 or 21 days for up to 4 sessions to prime and revitalise facial skin.
[METHOD] Delicate skin areas: periocular, décolleté, and hands
Polynucleotide-based treatments are effective and safe for rejuvenating delicate areas like the periocular region, décolleté, and hands. Using a microdroplet injection technique, 1-2 mL of 15 mg/2 mL PN-HPT™ gel is administered every 14-21 days for 3-4 sessions. This method addresses age-related changes and photodamage, ensuring predictable aesthetic improvements in thin-skinned areas.
[METHOD] Scalp
Intradermal injections of PN-HPT™ gel on the scalp promote hair thickening and revitalisation by stimulating hair follicles. A 2 mL injection of 15 mg in 2 mL PN-HPT™ gel is recommended per session, initially administered every 7 or 14 days for 4 sessions, followed by maintenance sessions every 21-30 days. This protocol, enhanced by complementary therapies, supports robust hair growth and improves hair shaft strength.
[METHOD] Stretch marks
To improve stretch marks and skin laxity, intradermal injections of PN-HPT™ are administered. Initially, 1-4 vials of PN-HPT™ combined with PNHA are injected every 7 or 14 days for 4 sessions, followed by maintenance sessions every 21-30 days for an additional 4 sessions. This approach, facilitated by techniques like needle microdroplets and linear retrograde injections, provides comprehensive treatment to address collagen bundles and elastin fibres’ deficiencies in the dermis.
Integration of Ameela® Polynucleotides into Clinical Practice
Training and Certification
Several institutions offer training and certification in polynucleotide therapies. For example, Acquisition Aesthetics UK provide various comprehensive courses on injectable treatments, including dermal filler, neurotoxin, and polynucleotides. These programmes include hands-on training guided by certified aesthetic trainers and theoretical knowledge to ensure aesthetic practitioners are well-prepared.
Upon completing the Polynucleotides Training Programme, you will receive a certification reflecting your commitment to excellence in regenerative aesthetics. But our support doesn’t end there. As part of our commitment to your professional growth, you will also have access to Acquisition Aesthetics’ faculty, additional training opportunities, and the chance to pursue the prestigious Level 7 diploma, further enhancing your aesthetic expertise and industry accreditation.
Book Polynucleotides Training Course Now (London and Newcastle)
Here’s a sneak peek of the before and after results with the pioneering Polynucleotide brand Ameela® in the Acquisition Aesthetics Polynucleotides Training Course.
Incorporating Ameela® Polynucleotide Therapies
Aesthetic practitioners can incorporate Ameela® polynucleotide therapies into their practice by attending our specialised training courses. The course covers the science behind polynucleotides, injection techniques, treatment planning, and patient selection criteria. Certification ensures aesthetic practitioners are equipped to safely and effectively administer these treatments superficially on the skin.
Why Train in The Ameela® Range?
- Complementary to Other Treatments
- High Patient Satisfaction
- Competitive Advantage
- Longer Lasting Effects
- Compliance and Safety
- Diverse Patient Base
Ameela® is a sterile, non-pyrogenic solution aligned with safety standards and regulations in the aesthetics industry. It is suitable for a wide range of patients with different skin concerns and goals, allowing aesthetic practitioners to cater to a diverse patient base and expand their practice. The range of Ameela® products are also viscoelastic and absorbable solutions based on polymerised polynucleotides. These are purified making them free from other components or proteins, which can trigger an immune response.
For more information, visit the Ameela page.
Polynucleotide Treatment: Challenges and Considerations
Safety and Efficacy
While polynucleotides are generally safe, aesthetic practitioners must be aware of potential side effects, such as temporary swelling, bruises, and redness. The needle size, the site of injection, the technique and speed of injection, and the product choice influence the potential for bruises. Several strategies may help to prevent or manage the occurrence of adverse events after polynucleotide treatments.
The main recommendations can be the avoidance of exposure to natural sunlight or sun lamps for 48 hours, applying soothing creams and ice packs, and the use of topical anaesthetics (eg, lidocaine) to reduce the discomfort associated with needle injections. These all are covered in the Acquisition Aesthetics Polynucleotides Training Course.
Additionally, choosing high-quality polynucleotide products and adhering to proper injection techniques are crucial for minimising risks. It’s also essential to manage patient expectations and provide thorough consultations to explain the gradual nature of polynucleotide treatments.
Patient Expectations
Patients should understand that polynucleotide treatments require time to show results. Unlike fillers, which offer immediate volumising effects, polynucleotides work at the cellular level and can take several weeks to months to produce visible improvements. Educating patients about the process and expected outcomes is vital for satisfaction.
The Future of Polynucleotides in Aesthetic Medicine
Future Innovations
Ongoing research is exploring new applications for polynucleotides in aesthetic medicine. Potential future uses include treating hyperpigmentation, enhancing wound healing, and combining polynucleotides with other regenerative treatments for synergistic effects. Advances in biotechnology may also lead to more effective and targeted polynucleotide therapies. Innovations such as using polynucleotide-rich serums, masks, and creams have already started gaining popularity among consumers looking for high-performance products that deliver visible results.
Ongoing Research
Current research is focused on understanding the mechanisms of action of polynucleotides and optimising their use in aesthetic treatments. Studies are investigating the long-term benefits and potential new indications for polynucleotides. This ongoing research will likely expand the scope of polynucleotide applications in aesthetic medicine. One example is the combination treatment for facial erythema resulting from inflammatory facial dermatosis and repeated laser/ microneedle radiofrequency, rather than from steroid overuse, in Korea.
Other ongoing research are vulvovaginal atrophy, iatrogenic fat atrophy, cutaneous ulcers, etc.
Polynucleotides FAQs
What are the costs associated with polynucleotide treatments in the UK?
Polynucleotide treatments can range from £400 to £1000 per session, depending on the treatment area, location, and product choice.
How long do the results last?
Results from polynucleotide treatments can last several months, with maintenance sessions recommended every 6-12 months for sustained benefits. The durations differ among varied polynucleotide products and patient’s existing skin conditions.
Who is a suitable candidate for polynucleotide treatments?
Most individuals looking to improve skin texture, reduce fine lines, or treat scars are suitable candidates. A thorough polynucleotide training with a qualified aesthetic trainer is necessary to determine eligibility as different polynucleotide products may have different patient selection criteria.
Aesthetic practitioners and researchers are encouraged to explore polynucleotide therapies and consider training in these advanced skincare treatments. Staying updated on the latest research and developments in polynucleotide applications can enhance clinical practice and improve patient outcomes.
Conclusion
Polynucleotides represent a significant innovation in aesthetic medicine, offering a natural and effective approach to skin regeneration and rejuvenation. By exploring and adopting these advanced therapies, aesthetic practitioners can provide patients with cutting-edge treatments that deliver longer-lasting results.
At Acquisition Aesthetics, we offer a specialised training ground with the pioneering Polynucleotide brand, Ameela®, in the Acquisition Aesthetics Polynucleotides Training Course. Our Polynucleotides Training Programme begins with a deep dive into the theoretical aspects of this groundbreaking solution coupled with hands-on practical training.
For more information about Acquisition Aesthetics and to register for other injectable courses, visit the Acquisition Aesthetics website today. Get hands-on experiences with our diverse team of qualified aesthetic trainers.
Call: 0203 514 8757
Email: contact@acquisitionaesthetics.co.uk.
